The evolution of allergy immunotherapy

ObjectiveThe objective of this review is to trace the evolution art and science allergy immunotherapy (AIT).Data SourcesOriginal reports relating concept respiratory its specific treatment were identified by following references in journal articles, textbooks from mid-20th century present.Study SelectionsStudies highlighting substantial milestones practice included.ResultsThe story AIT begins with recognition hay fever as a distinct entity subsequent studies that established grass pollen one causes. This knowledge led several investigators, most notable Leonard Noon John Freeman who worked at St. Mary’s Hospital London, attempt induce tolerance giving extract injection their patients. After publication work 1911, spread rapidly was applied many other allergens besides for perennial rhinitis asthma. The early largely anecdotal, but over past 60 70 years, have been conducted increasingly sophisticated scientific methods. Nowadays, not only based on carefully studies, underlying immunologic basis response also still are being firmly established.ConclusionBoth behind solid base clinical studies.